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Fluclotizolam

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Found in: 


Fentanyl, BZD

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Type/Reason added: 


DBZD

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Relative Potency: 


N/A

Treatment Options

Supportive Care: 

Airway protection and respiratory monitoring.

Antidote: 

Flumazenil may be administered in emergencies, though it can precipitate withdrawal in dependent users.

Pharmacokinetics and Dynamics

Metabolism: 

Fluclotizolam is metabolized in the liver, likely through the cytochrome P450 enzyme system, specifically CYP3A4. Its metabolites are excreted primarily via the urine.

Drug-Drug Interactions: 

Fluclotizolam has dangerous interactions with other depressants, including alcohol, opioids, and other sedative drugs, which significantly increase the risk of respiratory depression and fatal overdose. Medications that inhibit or induce CYP3A4 can alter its metabolism and effects.

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